The first BSD punch instruments were developed to improve workflow for newborn screening. Now decades later, the application of BSD punch instruments includes a wider audience of personal health diagnostics and multiplexed assays based on colorimetry, fluorescence, MS, HPLC and molecular methods.
Critical factors in health screening and diagnostics include the ability to consistently punch multiple aliquots from areas of a dried blood spot, with maximum throughput. Often, different downstream assays will require specific subsample amounts that correspond to punch tool diameters. BSD instruments allow punch sites to be pinpointed to remove specific areas of the sample when there is low sample volume or conformity.